Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation

Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation

Systemic inflammation correlates with an increased risk of atrial fibrillation (AF) and thrombogenesis. Systemic inflammation alters vessel permeability, allowing inflammatory and immune cell migration toward target organs, including the heart. Among inflammatory cells infiltrating the atria, macrop...

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Bibliographic Details
Main Authors: Raffaele Coppini, Lorenzo Santini, Chiara Palandri, Laura Sartiani, Elisabetta Cerbai, Laura Raimondi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
atrial fibrillation
coagulation
fibrosis
inflammation
protease-activated receptors
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01420/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01420/full

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