Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...

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Bibliographic Details
Main Authors: Teresa Buenaventura, Stavroula Bitsi, William E Laughlin, Thomas Burgoyne, Zekun Lyu, Affiong I Oqua, Hannah Norman, Emma R McGlone, Andrey S Klymchenko, Ivan R Corrêa, Abigail Walker, Asuka Inoue, Aylin Hanyaloglu, Jak Grimes, Zsombor Koszegi, Davide Calebiro, Guy A Rutter, Stephen R Bloom, Ben Jones, Alejandra Tomas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000097

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https://doi.org/10.1371/journal.pbio.3000097

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