PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interact...

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Main Authors: Kyle A. Cottrell, Hemangi G. Chaudhari, Barak A. Cohen, Sergej Djuranovic
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02745-0
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spelling doaj-860a849ac3354dd6b652646c9de5a8c52021-05-11T09:41:23ZengNature Publishing GroupNature Communications2041-17232018-01-019111310.1038/s41467-017-02745-0PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAsKyle A. Cottrell0Hemangi G. Chaudhari1Barak A. Cohen2Sergej Djuranovic3Department of Cell Biology and Physiology, School of Medicine, Washington UniversityDepartment of Genetics, School of Medicine, Washington UniversityDepartment of Genetics, School of Medicine, Washington UniversityDepartment of Cell Biology and Physiology, School of Medicine, Washington UniversityA large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interactions and consequences of RBP and miRNA binding.https://doi.org/10.1038/s41467-017-02745-0
collection DOAJ
language English
format Article
sources DOAJ
author Kyle A. Cottrell
Hemangi G. Chaudhari
Barak A. Cohen
Sergej Djuranovic
spellingShingle Kyle A. Cottrell
Hemangi G. Chaudhari
Barak A. Cohen
Sergej Djuranovic
PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
Nature Communications
author_facet Kyle A. Cottrell
Hemangi G. Chaudhari
Barak A. Cohen
Sergej Djuranovic
author_sort Kyle A. Cottrell
title PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_short PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_full PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_fullStr PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_full_unstemmed PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_sort ptre-seq reveals mechanism and interactions of rna binding proteins and mirnas
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interactions and consequences of RBP and miRNA binding.
url https://doi.org/10.1038/s41467-017-02745-0
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AT barakacohen ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas
AT sergejdjuranovic ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas
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