The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

ZBP1 and IMP2 belong to the IGF2BP family of RNA-binding proteins. Here the authors employed SELEX, NMR spectroscopy and mutagenesis to characterize the RNA-binding preference of ZBP1 and IMP2.

Bibliographic Details
Main Authors:	Jeetayu Biswas, Vivek L. Patel, Varun Bhaskar, Jeffrey A. Chao, Robert H. Singer, Carolina Eliscovich
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12193-7

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spelling	doaj-85ff9493a0c0443292b6df3d1c0104792021-05-11T11:48:57ZengNature Publishing GroupNature Communications2041-17232019-09-0110111010.1038/s41467-019-12193-7The structural basis for RNA selectivity by the IMP family of RNA-binding proteinsJeetayu Biswas0Vivek L. Patel1Varun Bhaskar2Jeffrey A. Chao3Robert H. Singer4Carolina Eliscovich5Department of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Radiation Oncology, Massachusetts General HospitalFriedrich Miescher Institute for Biomedical ResearchFriedrich Miescher Institute for Biomedical ResearchDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineZBP1 and IMP2 belong to the IGF2BP family of RNA-binding proteins. Here the authors employed SELEX, NMR spectroscopy and mutagenesis to characterize the RNA-binding preference of ZBP1 and IMP2.https://doi.org/10.1038/s41467-019-12193-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jeetayu Biswas Vivek L. Patel Varun Bhaskar Jeffrey A. Chao Robert H. Singer Carolina Eliscovich
spellingShingle	Jeetayu Biswas Vivek L. Patel Varun Bhaskar Jeffrey A. Chao Robert H. Singer Carolina Eliscovich The structural basis for RNA selectivity by the IMP family of RNA-binding proteins Nature Communications
author_facet	Jeetayu Biswas Vivek L. Patel Varun Bhaskar Jeffrey A. Chao Robert H. Singer Carolina Eliscovich
author_sort	Jeetayu Biswas
title	The structural basis for RNA selectivity by the IMP family of RNA-binding proteins
title_short	The structural basis for RNA selectivity by the IMP family of RNA-binding proteins
title_full	The structural basis for RNA selectivity by the IMP family of RNA-binding proteins
title_fullStr	The structural basis for RNA selectivity by the IMP family of RNA-binding proteins
title_full_unstemmed	The structural basis for RNA selectivity by the IMP family of RNA-binding proteins
title_sort	structural basis for rna selectivity by the imp family of rna-binding proteins
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	ZBP1 and IMP2 belong to the IGF2BP family of RNA-binding proteins. Here the authors employed SELEX, NMR spectroscopy and mutagenesis to characterize the RNA-binding preference of ZBP1 and IMP2.
url	https://doi.org/10.1038/s41467-019-12193-7
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The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

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