Effects of estrogen and luteinizing-releasing hormone on chromatin in CA3 region of male rat hippocampus

• Main Authors: Petrović Bojana, Drekić Dmitar, Zorić Zoran, Jović Slavoljub, Nikolić Milica, Ćupić-Miladinović Dejana
• Format: Article
• Language: srp
• Published: Faculty of Veterinary Medicine, Belgrade 2015-01-01
• Series: Veterinarski Glasnik
• Subjects: CA3 region; estrogen; hippocampus; LHRH; male rat
• Online Access: http://www.doiserbia.nb.rs/img/doi/0350-2457/2015/0350-24571504163P.pdf

The structure of heterochromatin protects genome from undesirable recombinations, while estrogen and luteinizing-releasing hormone (LHRH) cause changes in structure of chromatin. The objective of this study was to prove the connection of neonatally applied estrogen and LHRH, with shown effects on chromatin in hippocampus of adult male rats. Stereological results have shown that total surface of neuron area in estrogen treated animals significantly reduced in regard to the control group as well as groups treated with LHRH. The number of heterochromatin granules in either estrogen or LHRH treated groups significantly increased, while in the last fourth group treated with both estrogen and LHRH the difference is even more expressed, both in regard to the control group and other groups. [Projekat Ministarstva nauke Republike Srbije, br. 173034]