| Summary: | Introduction: The objective of the present study was to determine the effect of 10 weeks of high-intensity interval training (HIIT) and flaxseed oil supplement on heart IGF-1 concentration in male rats. Methods: Twenty adult male Wistar rats were randomly divided into saline, saline–training, supplementation, and supplementation–training groups. The training groups performed training (10 weeks, 5 sessions per week, 90%–95% VO2 max) on a rodent treadmill. The supplementation groups received flaxseed oil supplement (300 mg/kg). The rats were sacrificed 5 days after the last training session. The heart tissue was collected, and insulin-like growth factor-1 (IGF-1) was measured in the heart tissue. Results: Training increased the concentration of the heart IGF-1 (P=0.01). The concentration of heart IGF-1 was higher in the flaxseed oil-supplemented group than the saline-treated groups. (P=0.003). The interaction between training and supplementation also led to an increase in heart IGF-1 concentration (P=0.001). Conclusion: The increase of heart IGF-1 in trained supplemented group suggests that training and flaxseed oil can help to improve cardiac function.
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