Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a...

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Bibliographic Details
Main Authors:	Monika Kniotek, Agnieszka Boguska
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2017/4541958

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