CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma

• Main Authors: Zhou H, Su L, Liu C, Li B, Li H, Xie Y, Sun D
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-09-01
• Series: OncoTargets and Therapy
• Subjects: hepatocellular carcinoma; CTHRC1; biomarker; bioinformatics.
• Online Access: https://www.dovepress.com/cthrc1-may-serve-as-a-prognostic-biomarker-for-hepatocellular-carcinom-peer-reviewed-article-OTT

Huifang Zhou,1,2 Libo Su,3 Chao Liu,3 Baosheng Li,2 Hui Li,4 Ying Xie,3 Dianxing Sun1,2 1Graduate School of Hebei Medical University, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2The Liver Disease Center of PLA, The 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang, People’s Republic of China; 3Hebei Key Laboratory of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Department of Pathology, The 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang, People’s Republic of ChinaCorrespondence: Dianxing SunThe Liver Disease Center of PLA, The 980th Hospital of PLA Joint Logistics Support Force, 398 West Zhongshan Road, Shijiazhuang 050082, People’s Republic of ChinaTel [phone]Fax [phone]Email [e-mail] XieHebei Key Lab of Laboratory Animal Science, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, People’s Republic of ChinaTel [phone]Fax [phone]Email [e-mail]: Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding the role of CTHRC1 in hepatocellular carcinoma.Methods: Paraffin-embedded specimens from a total of 29 patients with HCC were collected in our study. The expression of CTHRC1 in hepatocellular carcinoma was evaluated using immunohistochemistry and bioinformatics analysis. Furthermore, Spearman analysis was performed to identify factors of correlation between CTHRC1 and clinicopathological features. Survival curves for hepatocellular carcinoma were produced using the Kaplan-Meier method and the log rank test.Results: In this study, we confirmed that CTHRC1 is highly expressed in tissues and hepatoma cell lines. The statistical analysis revealed that the levels of CTHRC1 were significantly correlated with cirrhosis (P=0.024), tumor size (P=0.006), vascular invasion (P<0.001), TNM stage (P<0.001), and BCLC stage (P<0.001). High expression of CTHRC1 in hepatocellular carcinoma tissues is significantly associated with poor survival.Conclusion: CTHRC1 may serve as a prognostic biomarker for hepatocellular carcinoma.Keywords: hepatocellular carcinoma, CTHRC1, biomarker, bioinformatics