Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

Abstract Background Identification of genomic biomarkers to predict the anticancer effects of indicated drugs is considered a promising strategy for the development of precision medicine. DNA endonuclease MUS81 plays a pivotal role in various biological processes during malignant diseases, mainly in...

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Bibliographic Details
Main Authors: Chengguo Li, Qian Shen, Peng Zhang, Tao Wang, Weizhen Liu, Ruidong Li, Xianxiong Ma, Xiangyu Zeng, Yuping Yin, Kaixiong Tao
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MUS81
WEE1
Immune checkpoint blocking
cGAS/STING pathway
Gastric cancer
Online Access:https://doi.org/10.1186/s13046-021-02120-4

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