Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER–Mitochondria Interface in Oncogene-Driven NSCLC

Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER–Mitochondria Interface in Oncogene-Driven NSCLC

Here, we tested whether co-targeting of glucose metabolism and oncogene drivers may enhance tumor response to tyrosine kinase inhibitors (TKIs) in NSCLC. To this end, pyruvate dehydrogenase kinase 1 (PDK1) was stably downregulated in oncogene-driven NSCLC cell lines exposed or not to TKIs. H1993 and...

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Bibliographic Details
Main Authors: Viviana De Rosa, Francesca Iommelli, Cristina Terlizzi, Eleonora Leggiero, Rosa Camerlingo, Giovanna G. Altobelli, Rosa Fonti, Lucio Pastore, Silvana Del Vecchio
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
PDK1
OXPHOS
glycolysis
apoptosis
drug resistance
Online Access:https://www.mdpi.com/2072-6694/13/16/4133

Internet

https://www.mdpi.com/2072-6694/13/16/4133

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