Delivery of miR-424-5p via Extracellular Vesicles Promotes the Apoptosis of MDA-MB-231 TNBC Cells in the Tumor Microenvironment

Delivery of miR-424-5p via Extracellular Vesicles Promotes the Apoptosis of MDA-MB-231 TNBC Cells in the Tumor Microenvironment

Programmed cell death ligand-1 (PD-L1) overexpressed on cancer cells has emerged as a key inhibitor that maintains the immunosuppressive microenvironment through its interaction with the PD-1 receptor in cancer. Here, we demonstrated that miR-424-5p delivery via extracellular vesicles (EVs) derived...

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Bibliographic Details
Main Authors: Yueyuan Zhou, Yusuke Yamamoto, Fumitaka Takeshita, Tomofumi Yamamoto, Zhongdang Xiao, Takahiro Ochiya
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
exosome
miR-424-5p
PD-L1
triple-negative breast cancer
mesenchymal stromal cell
Online Access:https://www.mdpi.com/1422-0067/22/2/844

Internet

https://www.mdpi.com/1422-0067/22/2/844

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