A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte
The activation of signal transducer and activator of transcription 3 (STAT3), as well as up-regulation of cytokines and growth factors to promote STAT3 activation, have been found in the epidermis of psoriatic lesions. Recently, a series of synthetic compounds possessing the Michael acceptor have be...
Main Authors: | A-Ram Kim, Seungbeom Lee, Jung U Shin, Seung Hui Seok, Young-Ger Suh, Dong Hyun Kim |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/16/8813 |
Similar Items
-
The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression
by: Tracess Smalley, et al.
Published: (2020-02-01) -
NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
by: Moon-Chang Choi, et al.
Published: (2019-07-01) -
IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes
by: Sofie Kaas Ovesen, et al.
Published: (2021-02-01) -
Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes
by: Ankit Srivastava, et al.
Published: (2018-05-01) -
14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling
by: Jia Song, et al.
Published: (2019-01-01)