Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Injectable therapeutic formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional administration routes. In this work, we proposed an alternative...

Full description

Bibliographic Details
Main Authors: Monica Boffito, Alessandro Torchio, Chiara Tonda-Turo, Rossella Laurano, Miguel Gisbert-Garzarán, Julia C. Berkmann, Claudio Cassino, Miguel Manzano, Georg N. Duda, María Vallet-Regí, Katharina Schmidt-Bleek, Gianluca Ciardelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
thermo-sensitive hydrogels
polyurethane
pH-sensitive mesoporous silica nanoparticles
self-immolative polymer
triggered drug release
stimuli-responsive
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00384/full

Similar Items

Similar Items