Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel DiseaseSummary

Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel DiseaseSummary

Background & Aims: Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier maintain gut homeostasis and defend against path...

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Bibliographic Details
Main Authors: Patti Hayes, Sandeep Dhillon, Kim OâNeill, Cornelia Thoeni, Ken Y. Hui, Abdul Elkadri, Conghui H. Guo, Lidija Kovacic, Gabriella Aviello, Luis A. Alvarez, Anne M. Griffiths, Scott B. Snapper, Steven R. Brant, James H. Doroshow, Mark S. Silverberg, Inga Peter, Dermot P.B. McGovern, Judy Cho, John H. Brumell, Holm H. Uhlig, Billy Bourke, Aleixo M. Muise, Ulla G. Knaus
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X15001071

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