Inhibition of GSK3 by lithium, from single molecules to signaling networks

For more than 60 years, the mood stabilizer lithium has been used alone or in combination for the treatment of bipolar disorder, schizophrenia, depression and other mental illnesses. Despite this long history, the molecular mechanisms trough which lithium regulates behavior are still poorly understo...

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Bibliographic Details
Main Authors: Laure eFreland, Jean-Martin eBeaulieu
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Akt
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00014/full