Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy

Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy

The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics can illustrate conformational transitions that play...

Full description

Bibliographic Details
Main Authors: Kwang-Im Oh, Jinwoo Kim, Chin-Ju Park, Joon-Hwa Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
nucleic acids
NMR
G-quadruplex
I-motif
triple helix
Z-DNA
Online Access:https://www.mdpi.com/1422-0067/21/8/2673
id doaj-85b6e7d638d44a8db36b541e7b4f0304
record_format Article
spelling doaj-85b6e7d638d44a8db36b541e7b4f03042020-11-25T03:10:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01212673267310.3390/ijms21082673Dynamics Studies of DNA with Non-canonical Structure Using NMR SpectroscopyKwang-Im Oh0Jinwoo Kim1Chin-Ju Park2Joon-Hwa Lee3Department of Chemistry and RINS, Gyeongsang National University, Gyeongnam 52828, KoreaDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Chemistry and RINS, Gyeongsang National University, Gyeongnam 52828, KoreaThe non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics can illustrate conformational transitions that play important roles in folding, stability, and biological function. Here, we discuss several examples of the non-canonical structures of DNA focusing on their dynamic characterization by NMR spectroscopy: (1) G-quadruplex structures and their complexes with target proteins; (2) i-motif structures and their complexes with proteins; (3) triplex structures; (4) left-handed Z-DNAs and their complexes with various Z-DNA binding proteins. This review provides insight into how the dynamic features of non-canonical DNA structures contribute to essential biological processes.https://www.mdpi.com/1422-0067/21/8/2673nucleic acidsNMRG-quadruplexI-motiftriple helixZ-DNA
collection DOAJ
language English
format Article
sources DOAJ
author Kwang-Im Oh
Jinwoo Kim
Chin-Ju Park
Joon-Hwa Lee
spellingShingle Kwang-Im Oh
Jinwoo Kim
Chin-Ju Park
Joon-Hwa Lee
Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
International Journal of Molecular Sciences
nucleic acids
NMR
G-quadruplex
I-motif
triple helix
Z-DNA
author_facet Kwang-Im Oh
Jinwoo Kim
Chin-Ju Park
Joon-Hwa Lee
author_sort Kwang-Im Oh
title Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
title_short Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
title_full Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
title_fullStr Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
title_full_unstemmed Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
title_sort dynamics studies of dna with non-canonical structure using nmr spectroscopy
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-04-01
description The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics can illustrate conformational transitions that play important roles in folding, stability, and biological function. Here, we discuss several examples of the non-canonical structures of DNA focusing on their dynamic characterization by NMR spectroscopy: (1) G-quadruplex structures and their complexes with target proteins; (2) i-motif structures and their complexes with proteins; (3) triplex structures; (4) left-handed Z-DNAs and their complexes with various Z-DNA binding proteins. This review provides insight into how the dynamic features of non-canonical DNA structures contribute to essential biological processes.
topic nucleic acids
NMR
G-quadruplex
I-motif
triple helix
Z-DNA
url https://www.mdpi.com/1422-0067/21/8/2673
work_keys_str_mv AT kwangimoh dynamicsstudiesofdnawithnoncanonicalstructureusingnmrspectroscopy
AT jinwookim dynamicsstudiesofdnawithnoncanonicalstructureusingnmrspectroscopy
AT chinjupark dynamicsstudiesofdnawithnoncanonicalstructureusingnmrspectroscopy
AT joonhwalee dynamicsstudiesofdnawithnoncanonicalstructureusingnmrspectroscopy
_version_ 1724656454745456640

Similar Items