Three-component radical homo Mannich reaction

Three-component radical homo Mannich reaction

Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl com...

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Main Authors: Shuai Shi, Wenting Qiu, Pannan Miao, Ruining Li, Xianfeng Lin, Zhankui Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21303-3
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spelling doaj-85b17ab32aad4d6a8bd0bf6d8e2bdfaa2021-02-14T12:11:33ZengNature Publishing GroupNature Communications2041-17232021-02-011211710.1038/s41467-021-21303-3Three-component radical homo Mannich reactionShuai Shi0Wenting Qiu1Pannan Miao2Ruining Li3Xianfeng Lin4Zhankui Sun5Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd.Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl compounds.https://doi.org/10.1038/s41467-021-21303-3
collection DOAJ
language English
format Article
sources DOAJ
author Shuai Shi
Wenting Qiu
Pannan Miao
Ruining Li
Xianfeng Lin
Zhankui Sun
spellingShingle Shuai Shi
Wenting Qiu
Pannan Miao
Ruining Li
Xianfeng Lin
Zhankui Sun
Three-component radical homo Mannich reaction
Nature Communications
author_facet Shuai Shi
Wenting Qiu
Pannan Miao
Ruining Li
Xianfeng Lin
Zhankui Sun
author_sort Shuai Shi
title Three-component radical homo Mannich reaction
title_short Three-component radical homo Mannich reaction
title_full Three-component radical homo Mannich reaction
title_fullStr Three-component radical homo Mannich reaction
title_full_unstemmed Three-component radical homo Mannich reaction
title_sort three-component radical homo mannich reaction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl compounds.
url https://doi.org/10.1038/s41467-021-21303-3
work_keys_str_mv AT shuaishi threecomponentradicalhomomannichreaction
AT wentingqiu threecomponentradicalhomomannichreaction
AT pannanmiao threecomponentradicalhomomannichreaction
AT ruiningli threecomponentradicalhomomannichreaction
AT xianfenglin threecomponentradicalhomomannichreaction
AT zhankuisun threecomponentradicalhomomannichreaction
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