A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity
Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit rib...
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MDPI AG
2015-06-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/7/6/1989 |
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doaj-85aee60568434ae1ac4b5cd71058aa5f2020-11-24T21:06:44ZengMDPI AGToxins2072-66512015-06-01761989200510.3390/toxins7061989toxins7061989A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular ToxicityYousef I. Hassan0Christena Watts1Xiu-Zhen Li2Ting Zhou3Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, CanadaGuelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, CanadaGuelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, CanadaGuelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, CanadaDeoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON’s toxicological profile, complementing the diverse symptoms associated with its exposure. This article summarizes the recent findings related to novel mechanisms of DON toxicity as well as how structural modifications to DON alter its potency. In addition, it explores feasible ways of expanding our understating of DON-cellular targets and their roles in DON toxicity, clearance, and detoxification through the utilization of computational biology approaches.http://www.mdpi.com/2072-6651/7/6/1989deoxynivalenoltoxicitymodificationenzymecomputational biology |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yousef I. Hassan Christena Watts Xiu-Zhen Li Ting Zhou |
| spellingShingle |
Yousef I. Hassan Christena Watts Xiu-Zhen Li Ting Zhou A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity Toxins deoxynivalenol toxicity modification enzyme computational biology |
| author_facet |
Yousef I. Hassan Christena Watts Xiu-Zhen Li Ting Zhou |
| author_sort |
Yousef I. Hassan |
| title |
A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity |
| title_short |
A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity |
| title_full |
A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity |
| title_fullStr |
A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity |
| title_full_unstemmed |
A Novel Peptide-Binding Motifs Inference Approach to Understand Deoxynivalenol Molecular Toxicity |
| title_sort |
novel peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity |
| publisher |
MDPI AG |
| series |
Toxins |
| issn |
2072-6651 |
| publishDate |
2015-06-01 |
| description |
Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON’s toxicological profile, complementing the diverse symptoms associated with its exposure. This article summarizes the recent findings related to novel mechanisms of DON toxicity as well as how structural modifications to DON alter its potency. In addition, it explores feasible ways of expanding our understating of DON-cellular targets and their roles in DON toxicity, clearance, and detoxification through the utilization of computational biology approaches. |
| topic |
deoxynivalenol toxicity modification enzyme computational biology |
| url |
http://www.mdpi.com/2072-6651/7/6/1989 |
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