Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma

Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma

Occult hepatitis B (OBI) is caused by a persistent low-level replication of HBV. Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We p...

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Main Authors: Vincenzo Pitini, Massimo Rizzo, Carmela Arrigo, Patrizia Mondello, Giuseppe Altavilla
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2012/803298
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spelling doaj-85aead0d5334423e8277242dd4a8b07c2020-11-24T20:40:43ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/803298803298Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell LymphomaVincenzo Pitini0Massimo Rizzo1Carmela Arrigo2Patrizia Mondello3Giuseppe Altavilla4Department of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, ItalyDepartment of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, ItalyDepartment of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, ItalyDepartment of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, ItalyDepartment of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, ItalyOccult hepatitis B (OBI) is caused by a persistent low-level replication of HBV. Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.http://dx.doi.org/10.1155/2012/803298
collection DOAJ
language English
format Article
sources DOAJ
author Vincenzo Pitini
Massimo Rizzo
Carmela Arrigo
Patrizia Mondello
Giuseppe Altavilla
spellingShingle Vincenzo Pitini
Massimo Rizzo
Carmela Arrigo
Patrizia Mondello
Giuseppe Altavilla
Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
Case Reports in Hematology
author_facet Vincenzo Pitini
Massimo Rizzo
Carmela Arrigo
Patrizia Mondello
Giuseppe Altavilla
author_sort Vincenzo Pitini
title Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
title_short Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
title_full Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
title_fullStr Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
title_full_unstemmed Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma
title_sort fatal hepatocellular carcinoma in a patient with occult hepatitis b virus infection following the administration of r-chop for diffuse large b-cell lymphoma
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2012-01-01
description Occult hepatitis B (OBI) is caused by a persistent low-level replication of HBV. Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.
url http://dx.doi.org/10.1155/2012/803298
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