Adenosine Receptor Agonist HE-NECA Enhances AntithromBotic Activities of Cangrelor and Prasugrel In Vivo by Decreasing of Fibrinogen Density in Thrombus

Adenosine Receptor Agonist HE-NECA Enhances AntithromBotic Activities of Cangrelor and Prasugrel In Vivo by Decreasing of Fibrinogen Density in Thrombus

Blood platelets’ adenosine receptors (AR) are considered to be a new target for the anti-platelet therapy. This idea is based on in vitro studies which show that signaling mediated by these receptors leads to a decreased platelet response to activating stimuli. In vivo evidence for the antithromboti...

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Bibliographic Details
Main Authors: Dawid Polak, Marcin Talar, Nina Wolska, Dagmara W. Wojkowska, Kamil Karolczak, Karol Kramkowski, Tomasz A. Bonda, Cezary Watala, Tomasz Przygodzki
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine receptors
P2Y<sub>12</sub> inhibitors
platelets
thrombosis
animal models
Online Access:https://www.mdpi.com/1422-0067/22/6/3074

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