Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.

Bibliographic Details
Main Authors: Hanxiao Liu, Xinxing Wang, Lu Chen, Liang Chen, Stella E. Tsirka, Shaoyu Ge, Qiaojie Xiong
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24915-x
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spelling doaj-85a4e328c23d4b989f9a8c639753deae2021-08-01T11:38:13ZengNature Publishing GroupNature Communications2041-17232021-07-0112111610.1038/s41467-021-24915-xMicroglia modulate stable wakefulness via the thalamic reticular nucleus in miceHanxiao Liu0Xinxing Wang1Lu Chen2Liang Chen3Stella E. Tsirka4Shaoyu Ge5Qiaojie Xiong6Department of Neurobiology and Behavior, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityHere, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.https://doi.org/10.1038/s41467-021-24915-x
collection DOAJ
language English
format Article
sources DOAJ
author Hanxiao Liu
Xinxing Wang
Lu Chen
Liang Chen
Stella E. Tsirka
Shaoyu Ge
Qiaojie Xiong
spellingShingle Hanxiao Liu
Xinxing Wang
Lu Chen
Liang Chen
Stella E. Tsirka
Shaoyu Ge
Qiaojie Xiong
Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
Nature Communications
author_facet Hanxiao Liu
Xinxing Wang
Lu Chen
Liang Chen
Stella E. Tsirka
Shaoyu Ge
Qiaojie Xiong
author_sort Hanxiao Liu
title Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_short Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_full Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_fullStr Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_full_unstemmed Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_sort microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.
url https://doi.org/10.1038/s41467-021-24915-x
work_keys_str_mv AT hanxiaoliu microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT xinxingwang microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT luchen microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT liangchen microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT stellaetsirka microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT shaoyuge microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
AT qiaojiexiong microgliamodulatestablewakefulnessviathethalamicreticularnucleusinmice
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