Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.

Bibliographic Details
Main Authors: Hanxiao Liu, Xinxing Wang, Lu Chen, Liang Chen, Stella E. Tsirka, Shaoyu Ge, Qiaojie Xiong
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24915-x
Description
Summary:Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.
ISSN:2041-1723

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