Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification

Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification

Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological charac...

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Main Author: Kentaro Inamura
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
histology
immunohistochemistry
kidney
genetic alteration
molecular pathology
renal cell carcinoma
Online Access:https://www.mdpi.com/1422-0067/18/10/2195
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spelling doaj-859a26e296cd46caa5abf64989f910122020-11-25T00:38:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-10-011810219510.3390/ijms18102195ijms18102195Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO ClassificationKentaro Inamura0Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, JapanAccumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors.https://www.mdpi.com/1422-0067/18/10/2195histologyimmunohistochemistrykidneygenetic alterationmolecular pathologyrenal cell carcinoma
collection DOAJ
language English
format Article
sources DOAJ
author Kentaro Inamura
spellingShingle Kentaro Inamura
Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
International Journal of Molecular Sciences
histology
immunohistochemistry
kidney
genetic alteration
molecular pathology
renal cell carcinoma
author_facet Kentaro Inamura
author_sort Kentaro Inamura
title Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
title_short Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
title_full Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
title_fullStr Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
title_full_unstemmed Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification
title_sort renal cell tumors: understanding their molecular pathological epidemiology and the 2016 who classification
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2017-10-01
description Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors.
topic histology
immunohistochemistry
kidney
genetic alteration
molecular pathology
renal cell carcinoma
url https://www.mdpi.com/1422-0067/18/10/2195
work_keys_str_mv AT kentaroinamura renalcelltumorsunderstandingtheirmolecularpathologicalepidemiologyandthe2016whoclassification
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