Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity

Proposed are the models for external exposure to and contamination with 137Cs (imitation of internal exposure) of human blood samples in vitro in doses up to 0.53 Gy for 1.75 h. Exposure conditions and experimental devices, as well as models for the calculation of the absorbed doses under external i...

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Main Authors:	L. K. Bezdrobna, M. V. Strilchuk, V. A. Kurochkina, V. I. Fedorchenko, I. A. Khomych, T. V. Tsyganok
Format:	Article
Language:	English
Published:	Institute for Nuclear Research, National Academy of Sciences of Ukraine 2020-06-01
Series:	Âderna Fìzika ta Energetika
Subjects:	137cs in vitro radiation simulation external exposure internal exposure human blood absorbed dose calculation.
Online Access:	http://jnpae.kinr.kiev.ua/21.2/Articles_PDF/jnpae-2020-21-0166-Bezdrobna.pdf

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spelling	doaj-85981d392a0e4aa5a9424469144326c92020-11-25T02:52:41ZengInstitute for Nuclear Research, National Academy of Sciences of UkraineÂderna Fìzika ta Energetika1818-331X2074-05652020-06-01212166171https://doi.org/10.15407/jnpae2020.02.166Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicityL. K. Bezdrobna0M. V. Strilchuk1V. A. Kurochkina2V. I. Fedorchenko3I. A. Khomych4T. V. Tsyganok5Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkraineProposed are the models for external exposure to and contamination with 137Cs (imitation of internal exposure) of human blood samples in vitro in doses up to 0.53 Gy for 1.75 h. Exposure conditions and experimental devices, as well as models for the calculation of the absorbed doses under external irradiation and estimation of the activity of the radioisotope needed to obtain the desired absorbed dose under internal exposure of blood cells, are presented. The created experimental models allow conduction of comparative in vitro studies of the 137Cs genotoxicity at external and internal exposure of human blood.http://jnpae.kinr.kiev.ua/21.2/Articles_PDF/jnpae-2020-21-0166-Bezdrobna.pdf137csin vitro radiation simulationexternal exposureinternal exposurehuman bloodabsorbed dose calculation.
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	L. K. Bezdrobna M. V. Strilchuk V. A. Kurochkina V. I. Fedorchenko I. A. Khomych T. V. Tsyganok
spellingShingle	L. K. Bezdrobna M. V. Strilchuk V. A. Kurochkina V. I. Fedorchenko I. A. Khomych T. V. Tsyganok Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity Âderna Fìzika ta Energetika 137cs in vitro radiation simulation external exposure internal exposure human blood absorbed dose calculation.
author_facet	L. K. Bezdrobna M. V. Strilchuk V. A. Kurochkina V. I. Fedorchenko I. A. Khomych T. V. Tsyganok
author_sort	L. K. Bezdrobna
title	Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity
title_short	Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity
title_full	Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity
title_fullStr	Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity
title_full_unstemmed	Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity
title_sort	simulation of conditions for external and internal exposure of human blood to low doses of 137cs radionuclide in vitro to study its genotoxicity
publisher	Institute for Nuclear Research, National Academy of Sciences of Ukraine
series	Âderna Fìzika ta Energetika
issn	1818-331X 2074-0565
publishDate	2020-06-01
description	Proposed are the models for external exposure to and contamination with 137Cs (imitation of internal exposure) of human blood samples in vitro in doses up to 0.53 Gy for 1.75 h. Exposure conditions and experimental devices, as well as models for the calculation of the absorbed doses under external irradiation and estimation of the activity of the radioisotope needed to obtain the desired absorbed dose under internal exposure of blood cells, are presented. The created experimental models allow conduction of comparative in vitro studies of the 137Cs genotoxicity at external and internal exposure of human blood.
topic	137cs in vitro radiation simulation external exposure internal exposure human blood absorbed dose calculation.
url	http://jnpae.kinr.kiev.ua/21.2/Articles_PDF/jnpae-2020-21-0166-Bezdrobna.pdf
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Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity

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