Simulation of conditions for external and internal exposure of human blood to low doses of 137Cs radionuclide in vitro to study its genotoxicity

• Main Authors: L. K. Bezdrobna, M. V. Strilchuk, V. A. Kurochkina, V. I. Fedorchenko, I. A. Khomych, T. V. Tsyganok
• Format: Article
• Language: English
• Published: Institute for Nuclear Research, National Academy of Sciences of Ukraine 2020-06-01
• Series: Âderna Fìzika ta Energetika
• Subjects: 137cs; in vitro radiation simulation; external exposure; internal exposure; human blood; absorbed dose calculation.
• Online Access: http://jnpae.kinr.kiev.ua/21.2/Articles_PDF/jnpae-2020-21-0166-Bezdrobna.pdf
• ISSN: 1818-331X; 2074-0565

Proposed are the models for external exposure to and contamination with 137Cs (imitation of internal exposure) of human blood samples in vitro in doses up to 0.53 Gy for 1.75 h. Exposure conditions and experimental devices, as well as models for the calculation of the absorbed doses under external irradiation and estimation of the activity of the radioisotope needed to obtain the desired absorbed dose under internal exposure of blood cells, are presented. The created experimental models allow conduction of comparative in vitro studies of the 137Cs genotoxicity at external and internal exposure of human blood.