| Summary: | Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression. Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10–20 system). Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10–20 sites to target the DLPFC. On the individual level, 20–40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the ‘optimal site for stimulation’. Conclusions: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network.
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