Immunological considerations and challenges for regenerative cellular therapies

Immunological considerations and challenges for regenerative cellular therapies

In this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the range of in vitro and in vivo approaches used to exa...

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Main Authors: Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02237-4
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spelling doaj-859349b557dc4c4183605d19cd5cdb442021-06-27T11:27:06ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111610.1038/s42003-021-02237-4Immunological considerations and challenges for regenerative cellular therapiesSandra Petrus-Reurer0Marco Romano1Sarah Howlett2Joanne Louise Jones3Giovanna Lombardi4Kourosh Saeb-Parsy5Department of Surgery, University of Cambridge, and NIHR Cambridge Biomedical Research CentrePeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, Guy’s HospitalDepartment of Clinical Neuroscience, University of CambridgeDepartment of Clinical Neuroscience, University of CambridgePeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, Guy’s HospitalDepartment of Surgery, University of Cambridge, and NIHR Cambridge Biomedical Research CentreIn this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the range of in vitro and in vivo approaches used to examine the immunogenicity of cellular therapies and consider potential confounders and strategies that can be employed to ameliorate immune rejection.https://doi.org/10.1038/s42003-021-02237-4
collection DOAJ
language English
format Article
sources DOAJ
author Sandra Petrus-Reurer
Marco Romano
Sarah Howlett
Joanne Louise Jones
Giovanna Lombardi
Kourosh Saeb-Parsy
spellingShingle Sandra Petrus-Reurer
Marco Romano
Sarah Howlett
Joanne Louise Jones
Giovanna Lombardi
Kourosh Saeb-Parsy
Immunological considerations and challenges for regenerative cellular therapies
Communications Biology
author_facet Sandra Petrus-Reurer
Marco Romano
Sarah Howlett
Joanne Louise Jones
Giovanna Lombardi
Kourosh Saeb-Parsy
author_sort Sandra Petrus-Reurer
title Immunological considerations and challenges for regenerative cellular therapies
title_short Immunological considerations and challenges for regenerative cellular therapies
title_full Immunological considerations and challenges for regenerative cellular therapies
title_fullStr Immunological considerations and challenges for regenerative cellular therapies
title_full_unstemmed Immunological considerations and challenges for regenerative cellular therapies
title_sort immunological considerations and challenges for regenerative cellular therapies
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description In this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the range of in vitro and in vivo approaches used to examine the immunogenicity of cellular therapies and consider potential confounders and strategies that can be employed to ameliorate immune rejection.
url https://doi.org/10.1038/s42003-021-02237-4
work_keys_str_mv AT sandrapetrusreurer immunologicalconsiderationsandchallengesforregenerativecellulartherapies
AT marcoromano immunologicalconsiderationsandchallengesforregenerativecellulartherapies
AT sarahhowlett immunologicalconsiderationsandchallengesforregenerativecellulartherapies
AT joannelouisejones immunologicalconsiderationsandchallengesforregenerativecellulartherapies
AT giovannalombardi immunologicalconsiderationsandchallengesforregenerativecellulartherapies
AT kouroshsaebparsy immunologicalconsiderationsandchallengesforregenerativecellulartherapies
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