Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation

Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation

This work demonstrates the effects of a newly synthesized conjugate of the plant triterpenoid betulin and the penetrating cation F16 used for mitochondrial targeting. The resulting F16-betulin conjugate revealed a mitochondria-targeted effect, decreasing the mitochondrial potential and inducing supe...

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Bibliographic Details
Main Authors: Mikhail V. Dubinin, Alena A. Semenova, Darya A. Nedopekina, Eldar V. Davletshin, Anna Yu. Spivak, Konstantin N. Belosludtsev
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Membranes
Subjects:
F16
betulin
thymocytes
mitochondria
oxidative phosphorylation
ROS
Online Access:https://www.mdpi.com/2077-0375/11/5/352

Internet

https://www.mdpi.com/2077-0375/11/5/352

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