Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11R/G31P

Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11R/G31P

The ELR-CXC chemokines are important to neutrophil inflammation in many acute and chronic diseases. Among them, CXCL8 (interleukin-8, IL-8), the expression levels of which are elevated in many inflammatory diseases, binds to both the CXCR1 and CXCR2 receptors with high affinity. Recently, an analogu...

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Bibliographic Details
Main Authors: Hsi-Tsung Cheng, Hui-Yuan Yu, John R. Gordon, Fang Li, Jya-Wei Cheng
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
CXCL8
antagonist
NMR
structure
mutation
Online Access:https://www.mdpi.com/1420-3049/22/7/1229

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