Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Abstract Vigabatrin (VGB; (S)‐(+)/(R)‐(‐) 4‐aminohex‐5‐enoic acid), an antiepileptic irreversibly inactivating GABA transaminase (GABA‐T), manifests use‐limiting ocular toxicity. Hypothesizing that the active S enantiomer of VGB would preferentially accumulate in eye and visual cortex (VC) as one po...

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Bibliographic Details
Main Authors: Dana C. Walters, Erwin E. W. Jansen, Garrett R. Ainslie, Gajja S. Salomons, Madalyn N. Brown, Michelle A. Schmidt, Jean‐Baptiste Roullet, K. M. Gibson
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Pharmacology Research & Perspectives
Subjects:
β‐alanine
4‐guanidinobutyrate
enantiomers
GABA
tissue distribution
Vigabatrin
Online Access:https://doi.org/10.1002/prp2.456

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