The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)

The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)

The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon...

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Bibliographic Details
Main Authors: Kelsey Gasior, Nikki J. Wagner, Jhon Cores, Rose Caspar, Alyson Wilson, Sudin Bhattacharya, Marlene L. Hauck
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
emt
tgf-β
cellular adhesion
epithelial
mesenchymal
breast carcinoma
colon carcinoma
Online Access:http://dx.doi.org/10.1080/19336918.2018.1526597
Description
Summary:The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells. While the SW480 population revealed an intermediate state between the epithelial and mesenchymal states, the MC7 cells exhibited highly adhesive behavior. However, for both cell lines, an exogenous TGF-β signal and a reduction in cellular confluence can push a subgroup of the population towards the mesenchymal phenotype. Together, these results highlight that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.
ISSN:1933-6918
1933-6926

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