Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes

Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes

Abstract Background Canonical nonsense-mediated decay (NMD) is an important splicing-dependent process for mRNA surveillance in mammals. However, processed pseudogenes are not able to trigger NMD due to their lack of introns. It is largely unknown whether they have evolved other surveillance mechani...

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Bibliographic Details
Main Authors: Liqiang Tan, Weisheng Cheng, Fang Liu, Dan Ohtan Wang, Linwei Wu, Nan Cao, Jinkai Wang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Biology
Subjects:
Pseudogene
N6-methyladenosine
Natural selection
ceRNA
RNA stability
Online Access:https://doi.org/10.1186/s13059-021-02402-2

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