Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.

Much is known about the regulatory elements controlling the cell cycle in fission yeast (Schizosaccharomyces pombe). This regulation is mainly done by the (cyclin-dependent kinase/cyclin) complex (Cdc2/Cdc13) that activates specific target genes and proteins via phosphorylation events during the cel...

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Main Authors: Dania Humaidan, Frank Breinig, Volkhard Helms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208515
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spelling doaj-854615655f274c50b81d095983546f262021-03-03T21:04:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020851510.1371/journal.pone.0208515Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.Dania HumaidanFrank BreinigVolkhard HelmsMuch is known about the regulatory elements controlling the cell cycle in fission yeast (Schizosaccharomyces pombe). This regulation is mainly done by the (cyclin-dependent kinase/cyclin) complex (Cdc2/Cdc13) that activates specific target genes and proteins via phosphorylation events during the cell cycle in a time-dependent manner. However, more work is still needed to complement the existing gaps in the current fission yeast gene regulatory network to be able to overcome abnormalities in its growth, repair and development, i.e. explain many phenomena including mitotic catastrophe. In this work we complement the previously presented core oscillator of the cell cycle of fission yeast by selected phosphorylation events and study their effects on the temporal evolution of the core oscillator based Boolean network. Thereby, we attempt to establish a regulatory link between the autonomous cell cycle oscillator and the remainder of the cell. We suggest the unclear yet regulatory effect of phosphorylation on the added components, and discuss many unreported points regarding the temporal evolution of the cell cycle and its components. To better visualize the results regardless of the programming background we developed an Android application that can be used to run the core and extended model of the fission yeast cell cycle step by step.https://doi.org/10.1371/journal.pone.0208515
collection DOAJ
language English
format Article
sources DOAJ
author Dania Humaidan
Frank Breinig
Volkhard Helms
spellingShingle Dania Humaidan
Frank Breinig
Volkhard Helms
Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
PLoS ONE
author_facet Dania Humaidan
Frank Breinig
Volkhard Helms
author_sort Dania Humaidan
title Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
title_short Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
title_full Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
title_fullStr Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
title_full_unstemmed Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
title_sort adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description Much is known about the regulatory elements controlling the cell cycle in fission yeast (Schizosaccharomyces pombe). This regulation is mainly done by the (cyclin-dependent kinase/cyclin) complex (Cdc2/Cdc13) that activates specific target genes and proteins via phosphorylation events during the cell cycle in a time-dependent manner. However, more work is still needed to complement the existing gaps in the current fission yeast gene regulatory network to be able to overcome abnormalities in its growth, repair and development, i.e. explain many phenomena including mitotic catastrophe. In this work we complement the previously presented core oscillator of the cell cycle of fission yeast by selected phosphorylation events and study their effects on the temporal evolution of the core oscillator based Boolean network. Thereby, we attempt to establish a regulatory link between the autonomous cell cycle oscillator and the remainder of the cell. We suggest the unclear yet regulatory effect of phosphorylation on the added components, and discuss many unreported points regarding the temporal evolution of the cell cycle and its components. To better visualize the results regardless of the programming background we developed an Android application that can be used to run the core and extended model of the fission yeast cell cycle step by step.
url https://doi.org/10.1371/journal.pone.0208515
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