Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive prope...

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Main Authors: Szekalska Marta, Amelian Aleksandra, Winnicka Katarzyna
Format: Article
Language:English
Published: Sciendo 2015-03-01
Series:Acta Pharmaceutica
Subjects:
ranitidine
sodium alginate
microspheres
spray drying technique
mucoadhesiveness
Online Access:https://doi.org/10.1515/acph-2015-0008
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spelling doaj-852a572e671d47679d787ff1a1352afa2021-09-06T19:39:38ZengSciendoActa Pharmaceutica1846-95582015-03-01651152710.1515/acph-2015-0008acph-2015-0008Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidineSzekalska Marta0Amelian Aleksandra1Winnicka Katarzyna2Department of Pharmaceutical Technology Medical University of Białystok 15-222 Białystok, PolandDepartment of Pharmaceutical Technology Medical University of Białystok 15-222 Białystok, Poland / Department of Clinical Pharmacy Medical University of Białystok 15-222 Białystok, PolandDepartment of Pharmaceutical Technology Medical University of Białystok 15-222 Białystok, PolandThe present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers - gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomachhttps://doi.org/10.1515/acph-2015-0008ranitidinesodium alginatemicrospheresspray drying techniquemucoadhesiveness
collection DOAJ
language English
format Article
sources DOAJ
author Szekalska Marta
Amelian Aleksandra
Winnicka Katarzyna
spellingShingle Szekalska Marta
Amelian Aleksandra
Winnicka Katarzyna
Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
Acta Pharmaceutica
ranitidine
sodium alginate
microspheres
spray drying technique
mucoadhesiveness
author_facet Szekalska Marta
Amelian Aleksandra
Winnicka Katarzyna
author_sort Szekalska Marta
title Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
title_short Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
title_full Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
title_fullStr Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
title_full_unstemmed Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
title_sort alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
publisher Sciendo
series Acta Pharmaceutica
issn 1846-9558
publishDate 2015-03-01
description The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers - gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach
topic ranitidine
sodium alginate
microspheres
spray drying technique
mucoadhesiveness
url https://doi.org/10.1515/acph-2015-0008
work_keys_str_mv AT szekalskamarta alginatemicrospheresobtainedbythespraydryingtechniqueasmucoadhesivecarriersofranitidine
AT amelianaleksandra alginatemicrospheresobtainedbythespraydryingtechniqueasmucoadhesivecarriersofranitidine
AT winnickakatarzyna alginatemicrospheresobtainedbythespraydryingtechniqueasmucoadhesivecarriersofranitidine
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