Prevalence of anti-HDV and HDAg in patients with chronic hepatitis B

• Main Authors: Mustafa Doğan, Hayati Güneş, Rafet Mete, Tekin Taş, Fırat Zafer Mengeloğlu, Abdulkadir Küçükbayrak
• Format: Article
• Language: English
• Published: Dicle University Medical School 2013-03-01
• Series: Dicle Medical Journal
• Subjects: Key words: HDV; HDAg; delta antigen; anti-HDV; chronic hepatitis B; pain
• Online Access: http://www.diclemedj.org/upload/sayi/26/Dicle%20Med%20J-01200.pdf

Objective: In this study, it is aimed to evaluate the correlationof the test results of anti-HDV and HDAg in patientswith chronic HBV infection and to collect data concerningHDV epidemiology.Materials and methods: Anti-HDV and HDAg test resultsand demographic data of the patients with chronic HBVinfection by gastroenterology and infectious diseasesin Agri State Hospital between January 2009-May 2012were analyzed retrospectively. HBsAg and Anti-HBc IgMtests were performed with macroelisa, anti-HDV andHDAg were tested with microelisa.Results: A total of 787 patients constituting 315(40.0%)females and 472(60.0%) males were included in thestudy. All the patients were HBsAg positive and Anti-HBcIgM negative. Of these patients, 55(7.0%) cases wereonly anti-HDV positive; 19(2.4%) were only HDAg positiveand two cases were both anti-HDV and HDAg positive.A total of 76(9.7%) patients had positive findings ofHDV infection. The mean age of HDV-positive patientswas 42.1±15.2 (11-77 years); of these 36(47.4) were femaleand 40(52.6) were male.Conclusion: In patients with chronic viral hepatitis, HDVinfection still remains significant. In our study HDV infectionrate was detected as 9.7%. Although this rate is lowerthan the earlier reports of the same region, it is above thenational average.Key words: HDV, HDAg, delta antigen, anti-HDV, chronic hepatitis B, pain