| Summary: | Howard JM Warren,1 Gabriela Ioachim,1 Jocelyn M Powers,1 Patrick W Stroman1– 3 1Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada; 2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada; 3Department of Physics, Queen’s University, Kingston, Ontario, CanadaCorrespondence: Patrick W StromanQueen’s University, Centre for Neuroscience Studies, 2nd Floor, Botterell Hall, 18 Stuart Street, Kingston, K7L 3N6, Ontario, CanadaTel +1-613-533-3245Email stromanp@queensu.caPurpose: The purpose of this study was to investigate the utility of data-driven analyses of functional magnetic resonance imaging (fMRI) data, by means of structural equation modeling, for the investigation of pain processing in fibromyalgia (FM).Patients and Methods: Datasets from two separate pain fMRI studies involving healthy controls (HC) and participants with FM were re-analyzed using both a conventional model-driven approach and a data-driven approach, and the results from these analyses were compared. The first dataset contained 15 women with FM and 15 women as healthy controls. The second dataset contained 15 women with FM and 11 women as healthy controls.Results: Consistent with previous studies, the model-driven analyses did not identify differences in pain processing between the HC and FM study groups in both datasets. On the other hand, the data-driven analyses identified significant group differences in both datasets.Conclusion: Data-driven analyses can enhance our understanding of pain processing in healthy controls and in clinical populations by identifying activity associated with pain processing specific to the clinical groups that conventional model-driven analyses may miss.Keywords: human, brain, pain, neuroimaging, fibromyalgia, chronic pain
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