Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.

Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.

MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour sup...

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Main Authors: Xiangyi Kong, Xiaofeng Xu, Yuhua Yan, Feifei Guo, Jian Li, Yali Hu, Huaijun Zhou, Qingying Xun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24595016/?tool=EBI
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spelling doaj-85155b81ceda47eeacd18e6bbe95efef2021-07-21T04:32:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9081010.1371/journal.pone.0090810Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.Xiangyi KongXiaofeng XuYuhua YanFeifei GuoJian LiYali HuHuaijun ZhouQingying XunMicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24595016/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Xiangyi Kong
Xiaofeng Xu
Yuhua Yan
Feifei Guo
Jian Li
Yali Hu
Huaijun Zhou
Qingying Xun
spellingShingle Xiangyi Kong
Xiaofeng Xu
Yuhua Yan
Feifei Guo
Jian Li
Yali Hu
Huaijun Zhou
Qingying Xun
Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
PLoS ONE
author_facet Xiangyi Kong
Xiaofeng Xu
Yuhua Yan
Feifei Guo
Jian Li
Yali Hu
Huaijun Zhou
Qingying Xun
author_sort Xiangyi Kong
title Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_short Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_full Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_fullStr Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_full_unstemmed Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_sort estrogen regulates the tumour suppressor mirna-30c and its target gene, mta-1, in endometrial cancer.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24595016/?tool=EBI
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AT xiaofengxu estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT yuhuayan estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT feifeiguo estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT jianli estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT yalihu estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT huaijunzhou estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
AT qingyingxun estrogenregulatesthetumoursuppressormirna30canditstargetgenemta1inendometrialcancer
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