Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which T cells develop this phenotype in solid tumors is needed. Here, hypoxia, a feature of the tumor microenvironment, causes T cell exhaustion (TExh) by inducing a mitochondrial defect. Upon ex...

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Bibliographic Details
Main Authors: Yi-Na Liu, Jie-Feng Yang, Dai-Jia Huang, Huan-He Ni, Chuan-Xia Zhang, Lin Zhang, Jia He, Jia-Mei Gu, Hong-Xia Chen, Hai-Qiang Mai, Qiu-Yan Chen, Xiao-Shi Zhang, Song Gao, Jiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
T cell exhaustion
mitochondrial dynamics
miR-24
nasopharyngeal carcinoma
MYC
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01906/full

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