An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer molecules, especially against breast, cervical, colo...
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Open Exploration Publishing Inc.
2020-06-01
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| Series: | Exploration of Targeted Anti-tumor Therapy |
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| Online Access: | https://www.explorationpub.com/Journals/etat/Article/100210 |
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doaj-8508a9474ce74049a62175b67818f8f22021-04-07T05:06:31ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142020-06-011315317010.37349/etat.2020.00010An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)Irum Naz0Myriam Merarchi1Shanaya Ramchandani2Muhammad Rashid Khan3Muhammad Nouman Malik4Sumaira Sarwar5Acharan S Narula6Kwang Seok Ahn7Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, PakistanFaculty of Pharmacy, University of Paris Descartes, 75006 Paris, FranceDepartment of Pharmacology-Biomedicine, The University of Melbourne, Parkville, VIC 3010, AustraliaHigher Education Commission of Pakistan, Islamabad 44000, PakistanDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, PakistanNarula Research, Chapel Hill, NC 27516, USADepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South KoreaTanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer molecules, especially against breast, cervical, colorectal, gastric, lung, and prostate cancer cell lines, as well as leukaemia, melanoma, and hepatocellular carcinoma among others. Recent data has indicated that Tanshinones can modulate multiple molecular pathways such as PI3K/Akt, MAPK and JAK/STAT3, and exert their pharmacological effects against different malignancies. In addition, preclinical and clinical data, together with the safety profile of Tanshinones, encourage further applications of these compounds in cancer therapeutics. In this review article, the effect of Tanshinones on different cancers, challenges in their pharmacological development, and opportunities to harness their clinical potential have been documented.https://www.explorationpub.com/Journals/etat/Article/100210tanshinonecancersignalling pathwaysapoptosisangiogenesispharmacokinetics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Irum Naz Myriam Merarchi Shanaya Ramchandani Muhammad Rashid Khan Muhammad Nouman Malik Sumaira Sarwar Acharan S Narula Kwang Seok Ahn |
| spellingShingle |
Irum Naz Myriam Merarchi Shanaya Ramchandani Muhammad Rashid Khan Muhammad Nouman Malik Sumaira Sarwar Acharan S Narula Kwang Seok Ahn An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) Exploration of Targeted Anti-tumor Therapy tanshinone cancer signalling pathways apoptosis angiogenesis pharmacokinetics |
| author_facet |
Irum Naz Myriam Merarchi Shanaya Ramchandani Muhammad Rashid Khan Muhammad Nouman Malik Sumaira Sarwar Acharan S Narula Kwang Seok Ahn |
| author_sort |
Irum Naz |
| title |
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) |
| title_short |
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) |
| title_full |
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) |
| title_fullStr |
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) |
| title_full_unstemmed |
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen) |
| title_sort |
overview of the anti-cancer actions of tanshinones, derived from salvia miltiorrhiza (danshen) |
| publisher |
Open Exploration Publishing Inc. |
| series |
Exploration of Targeted Anti-tumor Therapy |
| issn |
2692-3114 |
| publishDate |
2020-06-01 |
| description |
Tanshinone is a herbal medicinal compound described in Chinese medicine, extracted from the roots of Salvia miltiorrhiza (Danshen). This family of compounds, including Tanshinone IIA and Tanshinone I, have shown remarkable potential as anti-cancer molecules, especially against breast, cervical, colorectal, gastric, lung, and prostate cancer cell lines, as well as leukaemia, melanoma, and hepatocellular carcinoma among others. Recent data has indicated that Tanshinones can modulate multiple molecular pathways such as PI3K/Akt, MAPK and JAK/STAT3, and exert their pharmacological effects against different malignancies. In addition, preclinical and clinical data, together with the safety profile of Tanshinones, encourage further applications of these compounds in cancer therapeutics. In this review article, the effect of Tanshinones on different cancers, challenges in their pharmacological development, and opportunities to harness their clinical potential have been documented. |
| topic |
tanshinone cancer signalling pathways apoptosis angiogenesis pharmacokinetics |
| url |
https://www.explorationpub.com/Journals/etat/Article/100210 |
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