HLA A*32 is associated to HIV acquisition while B*44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

HLA A*32 is associated to HIV acquisition while B*44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

Abstract Background Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the driving force in pediatric HIV infection. We intended to look at the impact of the distribution of these polymorphic HLA ge...

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Bibliographic Details
Main Authors: Linda Mouafo Mekue, Céline Nguefeu Nkenfou, Elvis Ndukong, Leaticia Yatchou, Beatrice Dambaya, Marie-Nicole Ngoufack, Joel Kadji Kameni, Jules-roger Kuiaté, Alexis Ndjolo
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Pediatrics
Subjects:
HIV
Mother-to-child transmission
HIV acquisition
HLA genotype
Haplotype
Homozygosity
Online Access:http://link.springer.com/article/10.1186/s12887-019-1620-6

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