SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition

Abstract Background In our previous study, we demonstrated that Sirtuin 6 (SIRT6) is upregulated and associated with papillary thyroid cancer (PTC) progression (Qu et al. in Int J Oncol 50(5):1683–92, 2017). This study examined whether SIRT6 promotes epithelial–mesenchymal transition (EMT) of papill...

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Bibliographic Details
Main Authors: Zhou Yang, Weiping Yu, Renhong Huang, Min Ye, Zhijun Min
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
Sirtuin 6
Hypoxia inducible factor-1α
Papillary thyroid cancer
Epithelial–mesenchymal transition
Sirtuins
Online Access:http://link.springer.com/article/10.1186/s12935-019-0730-4

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http://link.springer.com/article/10.1186/s12935-019-0730-4

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