JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

<p>Abstract</p> <p>Background</p> <p>Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the acc...

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Bibliographic Details
Main Authors: Shrestha Sudeep, Zern Tosca L, West Kristy L, Aggarwal Dimple, Vergara-Jimenez Marcela, Fernandez Maria
Format: Article
Language:English
Published: BMC 2005-09-01
Series:BMC Cardiovascular Disorders
Online Access:http://www.biomedcentral.com/1471-2261/5/30

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