Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.

Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically glycosylated and aglycosylated hCES1, generat...

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Bibliographic Details
Main Authors: Victoria Arena de Souza, David J Scott, Joanne E Nettleship, Nahid Rahman, Michael H Charlton, Martin A Walsh, Raymond J Owens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4676782?pdf=render

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