IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

Foxp3+ regulatory T (Treg) cells are essential for the maintenance of immune homeostasis and tolerance. During viral infections, Treg cells can limit the immunopathology resulting from excessive inflammation, yet potentially inhibit effective antiviral T cell responses and promote virus persistence....

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Bibliographic Details
Main Authors: Iwana Schmitz, Christoph Schneider, Anja Fröhlich, Helge Frebel, Daniel Christ, Warren J Leonard, Tim Sparwasser, Annette Oxenius, Stefan Freigang, Manfred Kopf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3656089?pdf=render

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