Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells

Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote n...

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Main Authors:	Jing Xu, Xiaocong Sun, Xingyu Liu, Maoqin Peng, Shen Li, Da-Qing Jin, Dongho Lee, Mark Bartlam, Yuanqiang Guo
Format:	Article
Language:	English
Published:	Elsevier 2016-05-01
Series:	Journal of Functional Foods
Subjects:	Melicope pteleifolia Chroman Quinoline Alkaloids Neurite outgrowth
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464616300317

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spelling	doaj-84df2184a9be43cc9525777ecc0152082021-04-30T07:07:36ZengElsevierJournal of Functional Foods1756-46462016-05-0123565572Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cellsJing Xu0Xiaocong Sun1Xingyu Liu2Maoqin Peng3Shen Li4Da-Qing Jin5Dongho Lee6Mark Bartlam7Yuanqiang Guo8State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; Corresponding authors. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Tel.: +86 22 23502595; fax: +86 22 23502595.State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, ChinaSchool of Medicine, Nankai University, Tianjin 300071, ChinaDepartment of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of KoreaState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; Corresponding authors. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Tel.: +86 22 23502595; fax: +86 22 23502595.Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A–D (1–4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.http://www.sciencedirect.com/science/article/pii/S1756464616300317Melicope pteleifoliaChromanQuinolineAlkaloidsNeurite outgrowth
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jing Xu Xiaocong Sun Xingyu Liu Maoqin Peng Shen Li Da-Qing Jin Dongho Lee Mark Bartlam Yuanqiang Guo
spellingShingle	Jing Xu Xiaocong Sun Xingyu Liu Maoqin Peng Shen Li Da-Qing Jin Dongho Lee Mark Bartlam Yuanqiang Guo Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells Journal of Functional Foods Melicope pteleifolia Chroman Quinoline Alkaloids Neurite outgrowth
author_facet	Jing Xu Xiaocong Sun Xingyu Liu Maoqin Peng Shen Li Da-Qing Jin Dongho Lee Mark Bartlam Yuanqiang Guo
author_sort	Jing Xu
title	Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
title_short	Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
title_full	Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
title_fullStr	Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
title_full_unstemmed	Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
title_sort	phytochemical constituents from melicope pteleifolia that promote neurite outgrowth in pc12 cells
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2016-05-01
description	Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A–D (1–4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.
topic	Melicope pteleifolia Chroman Quinoline Alkaloids Neurite outgrowth
url	http://www.sciencedirect.com/science/article/pii/S1756464616300317
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Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells

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