Xenotransplantation today
The "mainstream" research in xenotransplantation concerns the pig organ/tissue engraftment to non human primates. During the last decade, a breakthrough in xenotransplantation research was made with transgenic pigs, resolving the problem of hyper-rejection. But, these pigs should undergo f...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2012-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2012/2490-33291201008I.pdf |
| Summary: | The "mainstream" research in xenotransplantation concerns the pig organ/tissue engraftment to non human primates. During the last decade, a breakthrough in xenotransplantation research was made with transgenic pigs, resolving the problem of hyper-rejection. But, these pigs should undergo further genetic manipulation to prevent expression of other antigens towards which at least some humans have naturally occurring antibodies. The most remarkable problem remains coagulation dysfunction between the recipient and donor. The life span of engrafted organs is still not good enough to get a long term therapeutic effect. Xenogenic transplantation is also concerned with the problem of transmissive biological agents and serious ethical issues. The long-term basic and pre-clinical studies are necessary to solve multilevel problems before the xenogenic organ transplantation comes to the clinical level, from non human primate to humans. |
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| ISSN: | 2490-3329 2303-7954 |