An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk

We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of...

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Main Authors: Linda E. Green, Tuan A. Dinh, Robert A. Smith
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Computational and Mathematical Methods in Medicine
Online Access:http://dx.doi.org/10.1155/2012/792375
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spelling doaj-84da5602ed0447048b3b150b4a8a65dd2020-11-24T20:59:14ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182012-01-01201210.1155/2012/792375792375An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer RiskLinda E. Green0Tuan A. Dinh1Robert A. Smith2Dominican University of California, 50 Acacia Avenue, San Rafael, CA 94901, USAArchimedes, Inc., 201 Mission Street, San Francisco, CA 94105, USAAmerican Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USAWe present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI (kg/m2) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users. When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI≥30. Model predictions agree with data from five major epidemiological studies.http://dx.doi.org/10.1155/2012/792375
collection DOAJ
language English
format Article
sources DOAJ
author Linda E. Green
Tuan A. Dinh
Robert A. Smith
spellingShingle Linda E. Green
Tuan A. Dinh
Robert A. Smith
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
Computational and Mathematical Methods in Medicine
author_facet Linda E. Green
Tuan A. Dinh
Robert A. Smith
author_sort Linda E. Green
title An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
title_short An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
title_full An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
title_fullStr An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
title_full_unstemmed An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
title_sort estrogen model: the relationship between body mass index, menopausal status, estrogen replacement therapy, and breast cancer risk
publisher Hindawi Limited
series Computational and Mathematical Methods in Medicine
issn 1748-670X
1748-6718
publishDate 2012-01-01
description We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI (kg/m2) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users. When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI≥30. Model predictions agree with data from five major epidemiological studies.
url http://dx.doi.org/10.1155/2012/792375
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