An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of...
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Series: | Computational and Mathematical Methods in Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/792375 |
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doaj-84da5602ed0447048b3b150b4a8a65dd2020-11-24T20:59:14ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182012-01-01201210.1155/2012/792375792375An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer RiskLinda E. Green0Tuan A. Dinh1Robert A. Smith2Dominican University of California, 50 Acacia Avenue, San Rafael, CA 94901, USAArchimedes, Inc., 201 Mission Street, San Francisco, CA 94105, USAAmerican Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USAWe present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI (kg/m2) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users. When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI≥30. Model predictions agree with data from five major epidemiological studies.http://dx.doi.org/10.1155/2012/792375 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Linda E. Green Tuan A. Dinh Robert A. Smith |
spellingShingle |
Linda E. Green Tuan A. Dinh Robert A. Smith An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk Computational and Mathematical Methods in Medicine |
author_facet |
Linda E. Green Tuan A. Dinh Robert A. Smith |
author_sort |
Linda E. Green |
title |
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk |
title_short |
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk |
title_full |
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk |
title_fullStr |
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk |
title_full_unstemmed |
An Estrogen Model: The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk |
title_sort |
estrogen model: the relationship between body mass index, menopausal status, estrogen replacement therapy, and breast cancer risk |
publisher |
Hindawi Limited |
series |
Computational and Mathematical Methods in Medicine |
issn |
1748-670X 1748-6718 |
publishDate |
2012-01-01 |
description |
We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The
model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI
(kg/m2) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users. When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI≥30. Model predictions agree with data from five major epidemiological studies. |
url |
http://dx.doi.org/10.1155/2012/792375 |
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