Prodifferentiation Activity of Novel Vitamin D2 Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

Prodifferentiation Activity of Novel Vitamin D2 Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

1α,25-dihydroxyvitamin D3 (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D2 is less toxic than vitamin D3 in animals. Here, w...

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Bibliographic Details
Main Authors: Matan Nachliely, Ehud Sharony, Narasimha Rao Bolla, Andrzej Kutner, Michael Danilenko
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
analogs of 1α,25-dihydroxyvitamin D2
vitamin D receptor
retinoid X receptor
carnosic acid
cell differentiation
cell cycle distribution
Online Access:http://www.mdpi.com/1422-0067/17/7/1068

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http://www.mdpi.com/1422-0067/17/7/1068

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