Association of Hepatitis Virus on Acute and Chronic Myeloid Leukemias. A pilot Study

• Main Authors: Abolfazl Movafagh, Farhad Shaveisi Zadeh, Ali Haeri, Mostafa Rezaei Tavirani, Mohammad Hassan Heidari, Ali Reza Mousavi Jarrahi
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2012-09-01
• Series: Basic & Clinical Cancer Research
• Subjects: Leukemia; AML; CML; HBV; Association
• Online Access: https://bccr.tums.ac.ir/index.php/bccrj/article/view/30
• ISSN: 2228-6527; 2228-5466

Background The induction of  cancers incidence by exogenous agents, such as chemical, radiation and especially research on viruses is an interested  area of active basic subjects  and clinical investigation. Prominent researches sounds a  high prevalence of HBV marker has been found in patients with leukemia as compared to the general population. Methods: Present   study was conducted from 1996  to 2010    among patients with chronic acute  myeloid leukemia and corresponding with non malignant patients. In this investigation,  Cytochemical staining, immunophenotyping, cytogenetic /molecular cytogenetics, Elisa, enzyme immunoassay and Western blot, were the main subject of laboratory manipulation. Results: Hepatitis B virus was diagnosed  in one non malignant control patient  (%0.004) and four infected with leukemia patients (%3). The differences of  leukemic patients revealed statistical significant when compared with non malignant patients (P=0.0047). Conclusion: In this pilot study, the prevalence of HBV infection was higher in patients with leukemia  than in patients as non malignant patients. Our findings are also important as they are among the first to suggest here a potentially significant influence of  HBV  infection may plays  a probably major role in the  process  of myeloid malignant  development. However, the number of cases are not large enough to draw firm conclusion. Moreover, we suggest that this pilot study, issue warrants further investigation by large consortium project.