Non-classical B Cell Memory of Allergic IgE Responses

The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and...

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Main Authors:	Sean P. Saunders, Erica G. M. Ma, Carlos J. Aranda, Maria A. Curotto de Lafaille
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-04-01
Series:	Frontiers in Immunology
Subjects:	allergy IgE memory B cells plasma cells anaphylaxis sequential switching
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00715/full

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spelling	doaj-84d322c9d5774a54a0246a1ca2b615d22020-11-25T01:08:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00715445571Non-classical B Cell Memory of Allergic IgE ResponsesSean P. Saunders0Erica G. M. Ma1Erica G. M. Ma2Carlos J. Aranda3Maria A. Curotto de Lafaille4Maria A. Curotto de Lafaille5Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United StatesDivision of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United StatesSackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United StatesDivision of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United StatesDivision of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United StatesDepartment of Cell Biology, New York University School of Medicine, New York, NY, United StatesThe long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory.https://www.frontiersin.org/article/10.3389/fimmu.2019.00715/fullallergyIgEmemory B cellsplasma cellsanaphylaxissequential switching
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sean P. Saunders Erica G. M. Ma Erica G. M. Ma Carlos J. Aranda Maria A. Curotto de Lafaille Maria A. Curotto de Lafaille
spellingShingle	Sean P. Saunders Erica G. M. Ma Erica G. M. Ma Carlos J. Aranda Maria A. Curotto de Lafaille Maria A. Curotto de Lafaille Non-classical B Cell Memory of Allergic IgE Responses Frontiers in Immunology allergy IgE memory B cells plasma cells anaphylaxis sequential switching
author_facet	Sean P. Saunders Erica G. M. Ma Erica G. M. Ma Carlos J. Aranda Maria A. Curotto de Lafaille Maria A. Curotto de Lafaille
author_sort	Sean P. Saunders
title	Non-classical B Cell Memory of Allergic IgE Responses
title_short	Non-classical B Cell Memory of Allergic IgE Responses
title_full	Non-classical B Cell Memory of Allergic IgE Responses
title_fullStr	Non-classical B Cell Memory of Allergic IgE Responses
title_full_unstemmed	Non-classical B Cell Memory of Allergic IgE Responses
title_sort	non-classical b cell memory of allergic ige responses
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2019-04-01
description	The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory.
topic	allergy IgE memory B cells plasma cells anaphylaxis sequential switching
url	https://www.frontiersin.org/article/10.3389/fimmu.2019.00715/full
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Non-classical B Cell Memory of Allergic IgE Responses

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